Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NCOA6 Polyclonal antibody

Uniprot No.

Q14686

Target Names

NCOA6

Alternative Names

NCOA6 antibody; AIB3 antibody; KIAA0181 antibody; RAP250 antibody; TRBP antibody; Nuclear receptor coactivator 6 antibody; Activating signal cointegrator 2 antibody; ASC-2 antibody; Amplified in breast cancer protein 3 antibody; Cancer-amplified transcriptional coactivator ASC-2 antibody; Nuclear receptor coactivator RAP250 antibody; NRC RAP250 antibody; Nuclear receptor-activating protein antibody; 250 kDa antibody; Peroxisome proliferator-activated receptor-interacting protein antibody; PPAR-interacting protein antibody; PRIP antibody; Thyroid hormone receptor-binding protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Nuclear receptor coactivator 6 protein (285-504AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Gene References into Functions

The retinoid x receptor does not interact with the NR box-1 of ASC-2, but functions as an allosteric activator of LXR binding to NR box-2 of ASC-2. PMID: 18031289
diverse physiological function of NCOA6 may be mediated by multiple isoforms expressed in different tissues and localized in different subcellular compartments PMID: 21552418
NCOA6 is responsible for the synergistic activation of CYP2C9 by HNF4alpha and pregnane X receptor and NCOA6 differentially regulates CYP2C9 and CYP3A4 gene expression though both the genes are regulated by the same nuclear receptors. PMID: 21292004
we show that ASC-2 belongs to a steady-state complex of approximately 2 MDa (ASC-2 complex [ASCOM]) in HeLa nuclei. ASCOM contains retinoblastoma-binding protein RBQ-3, alpha/beta-tubulins, and trithorax group proteins ALR-1, ALR-2, HALR, and ASH2. PMID: 12482968
interacts with and stimulates its associated DNA-dependent protein kinase PMID: 12519782
ASC-2 is a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism PMID: 12724417
ASC-2 appears to contain at least three distinct nuclear receptor interaction domains; also, Rb and ASC-2 have roles in androgen receptor transactivation PMID: 14645241
ASC-2 has a role in inducing target gene transcription during granulocytic differentiation through binding to ATF2 PMID: 14734562
results suggest that ASC-2 is a novel coactivator for HSF1 and heat shock stress may contribute to the strong active transcription complex through sequential recruitment of HSF1 and ASC-2. PMID: 14960326
ASC-2 is a bona fide coactivator of the xenobiotic nuclear receptor CAR and mediate the specific xenobiotic response by CAR in vivo. PMID: 15764585
interaction between RAP250, Smad2, and Smad3 constitutes an important bridging mechanism linking LXR and TGF-beta signaling pathways. PMID: 18263591
AIB3 contributes to the maintenance of beta-cell function in nondiabetic children and regulates gene expression in INS-1 cells. PMID: 18462265
The coactivator NCOA6 mediates the mechanism of the synergistic activation of the CYP2C9 gene by CAR and HNF4alpha. PMID: 18552123
Promoter analysis showed that PRIP acted through serum-responsive factor to regulate FOS gene expression. PMID: 19329434
The activation of DNA-PK in the absence of DNA ends by the coactivator TRBP suggests a novel mechanism of coactivator-stimulated DNA-PK phosphorylation in transcriptional regulation. PMID: 12519782